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A far-red hybrid voltage indicator enabled by bioorthogonal engineering of rhodopsin on live neurons

DA: Dopamine NE: Norepinephrine 5-HT: Serotonin SIRT-1: Silent mating type information regulation 2 homolog) 1 Bcl-2: B-cell lymphoma 2 Bax: Bcl-2 Associated X-protein MAPK: Mitogen-activated protein kinase IB: Inhibitor of nuclear factor kappa B PI3K: Phosphatidylinositol 3-kinase Akt: A serine/ threonine protein kinase mTOR: Mammalian target of rapamycin iNOS: Inducible Nitric oxide synthase SOD: Superoxide dismutase CAT: Catalase GPx: Glutathione peroxidase GSH: Glutathione NOX2: NADPH oxidase 2 H2AX: Histone H2A variant ET-1: Endothelin-1 eNOS: Endothelial nitric oxide synthase MCP-1: Monocyte chemoattractant protein-1 ACE: Angiotensin-converting enzyme gtfB: Glucotransferase B SPI1: Salmonellapathogenicity island 1 gtfC: Glucotransferase C HDL: High density lipoproteins PPAR: Peroxisome proliferator-activated receptor PPAR: Peroxisome proliferator-activated receptor UCP: Uncoupling protein 1 AMPK: 5' AMP-activated protein kinase MCP-3: Monocyte chemotactic protein 3 GLUT4: Glucose transporter type 4 CPT1B: Carnitine palmitoyltransferase IB ATGL: Adipose Triglyceride Lipase IL-6: Interleukin 6 IL-33: Interleukin 33 IL-1: Interleukin 1 TRPM8: Transient receptor potential ion channel 8 EBV EA: Epstein-Barr virus early antigen antibodies HBsAg: Hepatitis B surface antigen CTGF: Connective tissue growth factor TGF-beta (1): Transforming growth factor-beta (1) cccDNA: Covalently closed circular DNA CXCR4: C-X-C Chemokine Receptor 4 References Abd El Latif A, El Bialy BES, Mahboub HD, Abd Eldaim MA (2014) Moringa oleifera leaf extract ameliorates alloxan-induced diabetes in rats by regeneration of cells and reduction of pyruvate carboxylase expression

All groups were maintained under standard laboratory conditions (12-hour light/dark cycle, temperature 22 1 C, and free access to food and water)

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