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Then, 2 mg of SRS16-86 or SRS16-79 per kg body weight were dissolved in 2% DMSO and were applied intraperitoneally as a total volume of 400 L 15 min before the onset of surgery in all experiments

doi: 10.3390/molecules25204640

Currently, some prospective animal studies have begun exploring schemes combining drug administration with advanced biomaterials, yielding positive preliminary results, but their long-term efficacy and safety still require evaluation in larger-scale, in-depth studies

and are therefore more vulnerable and less tolerant to the pathogenic effects of mtDNA mutations ( The variation in copy number and stochastic nature of mitochondrial genetics results in a variable inheritance and expression pattern of heteroplasmic mutations