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Hyperglycemia can lead to excessive production of ROS, which is not only a major factor in aging, but also one of the leading causes of diabetes complications, insulin resistance, and mitochondrial dysfunction (63)

Zhang L, Wu M, Yu D, Teng Y, Wei T, Chen C, Song W (2018) Identification of glutathione peroxidase (GPX) gene family in Rhodiola crenulata and gene expression analysis under stress conditions

Because the condition results directly from retained toxins rather than primary inflammation, standard therapies like nonsteroidal anti-inflammatory drugs or colchicine are ineffective, making hemodialysis the only definitive, life-saving intervention

Dietary cobalt supplementation improves growth and body composition and induces the expression of growth and stress response genes in Tor putitora