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10.1016/j.febslet.2008.12.039 FEBS Lett

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In many cases, acute Lyme disease becomes chronic Lyme due to the involvement of co-infections, immune dysregulation, persister bacteria, biofilms, toxins, and cellular stress that complicate the treatment procedure and prolong the recovery time

The second patient maintained stable ERG responses throughout the study, indicating that the treatment did not worsen their condition, though it did not lead to significant improvement either (272)