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Introduction Following cessation of antiretroviral therapy (ART) in people with HIV (PWH), HIV rapidly rebounds from a pool of latently infected cells ( Several classes of LRAs with distinct mechanisms of action have been described, and many have demonstrated strong induction of HIV RNA in vitro and ex vivo ( in vivo , of which a common primary endpoint for efficacy has been cell-associated, unspliced HIV RNA as a measure of HIV reactivation (see ( This lack of potency of current LRAs is thought to be due to two reasons

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Atypical features, such as irritability and widespread somatic complaints (such as myalgia), are also commonly reported (36)