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In accordance with the imaging mass spectrometry results, GSH and GSSG levels were significantly elevated in kidneys with TLS, accompanied by an increased GSSG/GSH ratio (Figure 1J)

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We reasoned that if decreases in glutathione and glutamate in the stable phase are a consequence of damage arising in a preceding acute phase, a sample of stable patients would be more likely to demonstrate a reduction in these neurochemicals than a more heterogeneous sample