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PEO was able to indirectly modulate the Hedgehog pathway by inhibiting the activation of the PI3K-Akt pathway and further reducing inflammation in UC ( 4.3 Regulation of autophagy and apoptosis By interacting with the PI3K/Akt signaling pathway, the herbal monomers and their metabolites showed significant efficacy in regulating autophagy and apoptosis in UC

In contrast to apoptosis, necroptosis resembles necrosis through the rupture of the cell membrane and the release of pro-inflammatory factors (93)

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