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Simultaneously, the catabolite of indolepropionic acid acted as a ligand of the pregnane X receptor and showed the effect of adjusting the intestinal barrier function at the existence of indoles (Venkatesh et al., 2014)

Cell viability evaluated by MTT assay Viability of the cells was assayed using cell proliferation Kit I with the absorbance of 595 nm being detected using a Perkin-Elmer Victor plate reader

Based on these preclinical data, an early clinical study showed that solid grafts of adrenal medullary tissue, known to produce catecholamines, including dopamine, placed into the caudate nucleus through an open microsurgical procedure, had significant benefits in two patients with PD (Madrazo et al

S., Zeidler, J