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10.1046/j.1471-4159.2003.01854.x J

Antioxid Redox Signal , 1999

Additionally, mRNA expression of iron response element binding protein 2, encodes a master regulator of iron metabolism), and CS (citrate synthase, regulating the mitochondrial fatty acid metabolism) was upregulated in both models, while ACSF2 ((acyl-CoA synthetase family member 2, regulating the mitochondrial fatty acid metabolism) was upregulated only in APPswe/PS1dE9 mice

Treatment with ATR-127 in diet-induced mice with obesity showed that ATR-127 effectively improved glucose homeostasis, reduced body weight and fat mass, enhanced skeletal muscle glucose uptake, increased brown adipose tissue thermogenesis, and improved hepatic steatosis 55