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Description

The NALP3 inflammasome is involved in the innate immune response to amyloid-beta

10.1007/s10863-017-9704-1 J

The released mtDNA activates the cGAS-STING-TBK1 pathway, inducing the secretion of type I interferons (IFN-/), which subsequently upregulate PD-L1 and IDO-1 expression via JAK-STAT signaling, directly suppressing the antitumor function of CD8+ T cells