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Original Investigation

A.KalinderiK.PapamitsouT.PapaliagkasV

doi: 10.1038/nrn1256 65 GlumacS.KardumG.SodicL.BulatC.CovicI.CarevM.et al

Definition of cell senescence Although research on cell senescence lasts for decades, until recently, the field reached a consensus on the definition of cell senescence, that is, a type of cell state that can be stimulated by multiple stress signals throughout the life cycle and is characterized by cell cycle arrest, senescence-associated secretory phenotype (SASP), and dysregulated metabolism and macromolecular damage 1 (Fig