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Jeffery, N

However, since many cell lines are strictly dependent on exogenous serine for proliferation, we hypothesized that NKX2-1 overexpression could overcome this limitation

Further, -cyanoalanine is enzymatically converted to asparagine (by an enzyme of nitrilase activity) or aspartate and ammonium (by an enzyme of nitrile hydratase) (Piotrowski et al