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Randomized and longitudinal studies have shown that folic acid and vitamin B12 supplementation modify DNA methylation profiles, both globally and at specific loci, consistent with enhanced methyl-group availability for DNMT-mediated reactions (104-106)

Li H, Liu Y, Xiao Y, Wilson CN, Bai HJ, Jones MD, et al

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The PeredoxDS construct was obtained after two rounds of mutagenesis on the p413TEF Peredox plasmid using primer pairs Pr3/Pr4 and Pr5/Pr6 ( Supplementary Table 6 )