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We found that RNF4 enhanced the tumorigenic properties of cancer cells and was essential for cancer cell survival

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On the one hand, intestinal microbes modify BAs through enzymatic transformations

85 This is of particular importance because some xenobiotics might impact the GI microbiota physiology without inducing dysbiosis: indeed, when fresh human faecal samples were incubated with antibiotics or with host-targeted drugs, all host-targeted drugs resulted in significant alterations of microbial gene expression, including genes involved in xenobiotic metabolism, despite minimal short-term effects on microbial community structure