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Age-related macular degeneration is something that happens to many people as they get older, and often it causes mobility issues later in life

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This leads to the release and subsequent cytoplasmic translocation of p53, which in turn activates a transcription-independent pro-apoptotic pathway, facilitating the selective clearance of senescent cells (Kong et al., 2025

This finding highlights the important role of amino acid recycling by the 26S proteasome in cellular survival, although it remains unclear how free amino acid content affects cellular physiology