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Researchers who add too many variables simultaneously cannot identify which compound is producing which effect, making troubleshooting impossible

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A 2021 peer-reviewed review of NNMT in obesity and type 2 diabetes states explicitly that 'clinical trials targeting NNMT have not been reported' meaning every quantitative efficacy figure available for this compound comes from mice, and there is currently zero published human efficacy data

10.1016/j.phymed.2024.155646 109 MeihuaJ.ChunW.YifengX.ZijingZ.XueyanW.RunfaY.et al (2022)