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Calorie restrictive diet and intermittent fasting also have an influence on the gut microbiome

The ingestion of dietary fats and the oxidative metabolism of ethanol alter ER inducing ER stress, which emerges as a critical trigger to cause increased de novo lipogenesis, including free fatty acids (FFAs) and cholesterol via activation of transcription factors SREBP1c and SREBP2, respectively, with the ultimate impact in the onset of hepatic steatosis

This finding is in line with the time-independent reduction of IFNGR1 and IFNAR2 expression detected in the cytoplasm of AM from PrEP at the bulk stage ( Figure 2E )