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Higher temps pose greater risk of scald 140 is used to kill bacteria, most residential water heater thermostats have high temp range 150, while some commercial tanks can deliver 180

10.1016/j.bioorg.2004.06.005 61 RabahiF.BrlS.SiroisJ.BeckersJ

It has recently been demonstrated in macrophages that lactate via GPR81/ARRB2 increases acetylation of HMGB1 by inducing nuclear translocation of acetylase p300/CBP resulting in increased endothelium permeability (162)