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Case 5: Repeated Supratherapuetic Ingestion A 38-year-old male presents with a toothache for the past 3 days

Reproduc Biomed Online

Chaouachi M, Gautier S, Carnot Y, Guillemot P, Pincemail J, Moison Y, et al

Mechanisms that inhibit propagation of the DNA damage signal to the apoptotic machinery include loss of damage recognition, overexpression of HER-2/neu, activation of the PI3-K/Akt (also known as PI3-K/PKB) pathway, loss of p53 function, overexpression of antiapoptotic bcl-2, and interference in caspase activation