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In pre-clinical studies, Sven Wehners group identified IL-1 and IL-1R signaling in enteric glia as a potential contributing mechanism to GI motility disruption and POI

Compared with the reserpine group, the green coffee group also presented a moderate but statistically significant decrease in Iba-1 immunoexpression

SdaA was reported to be the gene encoding either the structural gene of L-SD that catalyzes the deamination of serine to pyruvate or a positive activator of transcription [31]

While diet should certainly be seen as the primary source of nutrients required to protect us against oxidative stress, supplementation can be highly beneficial where diet falls short or when an increased need arises