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The damage caused in the brain by MS is macro-structural (i.e., brain atrophy and volume loss) and microstructural (e.g., disrupted white matter integrity), involving precise areas of the nervous system (Jameen et al., 2019)

Factors that induce the production of advanced glycation end products (AGEs) AGE levels in blood and tissues depend on endogenous sources (chemical reactions) and exogenous sources (diet and smoking)