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A published article confirmed that no increase in SOD2 expression was detected in primary neurons or astrocytes, while the mRNA and protein levels of SOD2 were significantly increased in rat primary microglia treated with LPS, poly (I:C), peptidoglycan, or CpG oligodeoxynucleotides, suggesting that SOD2 was specifically induced in microglia under inflammatory conditions [59]

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Then, using extended 20 s of coarse-grained simulations to refine the initial models in a solvated box, it was found that the M105I model shortens its total size by an average of ~17 with respect to the WT structure (Supplementary Fig

Micronized PEA, at doses of 6001,200 mg/day, reduced pain in subjects with diabetes- or trauma-related nerve pain, chronic pain after failed back surgery, and acute pain from tooth extraction (Cocito 2014