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Key Points IGF1R is expressed in a large range of tumors and is crucial for tumor transformation and survival of malignant cells IGF1R signaling interferes with numerous growth factors and receptors pathways such as VEGF and EGFR, and IGF1R signaling has been found to correlate with resistance to both anti-EGFR therapies and those that target HER2 Several monoclonal antibodies and smallmolecular inhibitors are being tested in preclinical and clinical studies

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Hypoxia promotes GSH synthesis in seal cells High tissue and circulating GSH levels, as well as high activity of many glutathione-dependent antioxidant enzymes, including glutathione peroxidases (GPX) and glutathione S -transferases (GST) [18, 20,21,22, 63], suggest a critical role for GSH in protecting diving mammals against oxidative stress

The results of our study suggest that Remo has anti-inflammatory and antioxidant properties that protect against TAA-induced liver fibrosis by inhibiting the NF-B pathway and activating the AMPK/SIRT1/Nrf2 pathway