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First of all, its an evolutionary non-sequitur

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It also positively impacts platelet-activating factors, metabolism, oxygen consumption, bone formation and the tolerance of toxin exposure

Pyroglutamic acid (5-oxoproline), a glutamate cyclized derivative, also presented a higher abundance in OVX rat serum/urine samples that was significantly reversed by HPL therapy (Figure 3D, metabolite determination results are shown in Supplementary Tables S10)