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doi: 10.1128/AEM.02391-12 82 MetzlerM.PfeifferE.HildebrandA

demonstrated that AC synergistically enhanced the cytotoxic abilities of 5-FU, caused G1 cell cycle arrest, and promoted apoptosis by modulating the anti-apoptotic B-cell lymphoma 2 (Bcl2) and the pro-apoptotic Bcl-2-associated X protein (Bax), and to a lesser degree, Bcl-xL and p53