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In a primary culture of orbital fibroblasts from GO patients and control subjects treated with H 2 O 2 to induce OS, the antioxidants vitamin C, N-acetyl-L-cysteine, melatonin, retinol, -carotene and vitamin E were found to reduce the manifestations OS (proliferation of fibroblasts, the level of hyaluronic acid, the level of tumor necrosis factor- (TNF-), IFN- and IL1-, which provided the basis for the possible clinical use of these substances in patients with GO (87)

Akkan and M.E

[DOI] [PubMed] [Google Scholar] Pawar PV, Mumbare SS, Patil MS, Ramakrishnan S, 2014

A pilot study has been performed on 28 patients (23 males and five females) to evaluate the efficiency of curcumin in decreasing TGF- levels