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This kind of apoptosis is independent of mitochondria and relies on ATG5, which means the involvement of autophagy

Key accelerators include: Mitochondrial dysfunction: Leading to reduced energy output and increased reactive oxygen species (ROS)

Accordingly, novel technologies such as liquid biopsy, high-dimensional cytology, single-cell omics, metabolomics, and high-resolution imaging could be used to discover more easily detected biomarkers, bringing great convenience to drug-resistant cancer treatment

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