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Description

There was no significant difference in mean GH peaks between leptin-deficient and leptin-replete controls, suggesting that leptin does not play a significant role in the GH suppression seen in obese humans, and that the decreased GH secretion of obesity is mediated via other mechanisms (383)

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Research Applications in Preclinical Research and Animal Models Much of what is currently known about peptide biology originates from preclinical models

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