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Genetic ablation of the Abcb1a gene caused near-complete phenotypic reversal, namely a significant down-regulated ROS accumulation, with the fold changes ranging from 1.20 to 3.02, in liver, blood, and spleen of resistant subgroups versus the sensitive groups, independent of therapeutic modalities (Fig

Based on directed acyclic graph analysis and previous literature 55,56,57,58 , variables such as age, education, residence, smoking, and drinking were considered as potential confounders (Supplementary Fig

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Moreover, stereotaxic lactate injection into the third ventricle induces PD-like phenotypes, including motor impairments, in murine models 8