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Network biology implemented computational models to interpret gene regulatory networks (GRNs) (289), protein-protein interaction (PPI) networks (290) and signaling cascades (291), characterizing the key modules, hubs, and bottlenecks linked with cancer phenotypes

However, the subjects in these studies were likely treated with the bronchodilator, theophylline, which is a vitamin B 6 antagonist and results in decreased circulating vitamin B 6 levels in treated subjects (294, 324)

4f), which suggested that the untethered ligand does not specifically accumulate in the endolysosomal compartment

Cells acquire cysteine mainly by macrophage and lymphocyte uptake, and impaired immune responses are associated with a reduction in GSH concentration (Drge and Breitkreutz, 2000