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Nature 509, 96100

Mechanism-Based Combinatorial Strategy for Overcoming FLT3-Inhibitor Resistance in Dual FLT3 ITD and TKD Point Mutations

These data suggest that ATF4 deficiency increases ROS levels in cells, but the accumulation of ROS has been shown to prevented by chelation of the iron internalized by cells, and the effects produced by ATF4 overexpression can be inhibited by sorafenib and erastin (76, 77)