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For instance, MYC, which is a well-known regulator of metabolism that controls glycolysis, glutamine transport and metabolism, lipid metabolism, and mitochondrial biogenesis, was more active in the high GSH metabolism group, suggesting that elevated GSH levels may drive tumor cell metabolic demands and rapid proliferation through MYC activation ( Further examination of 12 transcription factors closely associated with immune function demonstrated marked differences between the high and low GSH metabolism groups

These processes are particularly critical in neurodegenerative diseases such as AD, PD, amyotrophic lateral sclerosis and Huntingtons disease (Thapa et al., 2021

In contrast, lung cancer cells upregulate the ASCT2 transporter to aggressively uptake glutamine, fueling their bioenergetic demands [11]

In coronary artery disease, lycopene was found to effectively increase GSH levels and decrease MDA levels (Misra et al., 2006)