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As a hexapeptide derivative, Dihexa has drawn significant attention in the scientific community due to its capacity to influence molecular pathways associated with synaptic plasticity and cognitive function

The restraints were derived from (i) NOE restraints from intermolecular and intramolecular cross-peaks in NOESY spectra (described in NMR spectroscopy section), (ii) TALOS derived p53 TAD2 and FOXO4-DRI backbone dihedral angles, (iii) hydrogen bond restraints (regions p53 residues 4752, FOXO4-DRI residues 918

However, the aforementioned study involved only 20 subjects who self-applied skin products and overall the study methodology was highly questionable

Treatment with FOXO4-DRI led to the nuclear exclusion of active Ser15-phospho-p53 in senescent cells