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Conversely, elevated membrane cholesterol reduces insulin-degrading enzyme (IDE) and neprilysin (NEP) activity, impairing A transport and clearance, thereby promoting SP formation (Wang et al., 2019)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 16.Hartman RE, Patel D

Lastly, albeit often unaddressed or underexplored, cognitive impairments and sleep disorders remain prevalent in 6080% of survivors, even after treatment, and can significantly impact the quality of life in these patients