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Factors such as activation of myo-fibroblasts, EMT of PMCS, biomechanical injuries, epigenetics and gut microbiota, bioincompatible PD fluid-induced sterile inflammation, peritonitis, peritoneal angiogenesis are all involved in the occurrence of peritoneal fibrosis

2.2 Major exposure pathways and representative cases Human EED exposure occurs through multiple routes, with patterns varying significantly based on occupational activities, environmental conditions, and consumer behaviors