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Further, it seems odd to start off with these disorders because there is nothing cited to specifically implicate ghrelin therapeutics for these conditions. Response: In order to reduce speculation, we have removed the sections on D1R-GHSR1as possible role in Alzheimers, 5-HT2C-GHSR1as possible role in depression, anxiety, and stress, and D2R-GHSR1as possible role in antipsychotic-associated weight gain (although we have added an additional section pertaining to 5-HT2C-GHSR1as possible role in schizophrenia, along with considerable references to support our argument)

The default is once daily, continuous

This clean, targeted response gives researchers insight into how growth hormone can be released in short, controlled bursts