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Glia 65 , 18481862 (2017)

In addition, core myelin structural genes were selectively downregulated in CPZ DAOs and MS lesions, reinforcing the disease relevance of this state

[DOI] [PubMed] [Google Scholar] 234

Systemic administration (injectable or oral), which is less common than topical use and not part of approved or standard applications, would theoretically carry different safety considerations requiring appropriate clinical evaluation, though limited research on parenteral administration in animals has suggested acceptable safety profiles at moderate doses