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The secondary C3-amine derivative intermediate (e.g., compound 9) may then be methylated to obtain the desired cation (e.g., compound 1f)

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While the general population may only occasionally hear about vitamin B12 in the context of tiredness or "energy boosters," for those living without certain sections of the gut, it can become a chronic, insidious deficiency, often difficult to detect and even harder to address without clinical awareness