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doi: 10.3389/fmars.2024.1495373 227 TresguerresM.KwanG

Nanoparticle-based delivery of small interfering RNA: Challenges for cancer therapy

On the other hand it is known that glutamine, the most abundant free amino acid in blood, is uptaked by tumor cells and converted into -ketoglutarate (-KG) that fuels the tricarboxilic acid (TCA) cycle and OXPHOS in tumor mitochondrial

This increased ATP consumption in astrocytes leads to greater glucose uptake, mediated by an increase in glucose transporter production, which in turn boosts glycolysis and lactate production via LDHA