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Roles of plant retinoblastoma protein: cell cycle and beyond

Barman, P., Joshi, S., Sharma, S., Simran Preet, Sharma, S., & Saini, A

Studies demonstrate that Dihexa promotes dendritic spine formation, increases synaptic density, and enhances miniature excitatory postsynaptic currents (mEPSCs), indicating the formation of functional glutamatergic synapses

However, efforts must also focus on the interim strategy to slow neuron losses in brain structures impacted including neocortices, hippocampus, locus ceruleus and the nucleus basalis of Meynert by stimulating synaptogenesis, neurogenesis and reducing neuroinflammation and oxidative stress