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Because an oral 15-PGDH inhibitor has already passed Phase 1 safety testing in humans for age-related #muscle weakness, the authors are hopeful that clinical trials in joint disease will follow, potentially paving the way for #nonsurgical, cartilage-regenerating therapies that could delay or replace knee and hip replacements

J Clin Child Adolesc Psychol

Nonetheless, the existence of a biological interplay among OS, aging, and ALS has been presumed for more than two decades [325] and it is now becoming more evident [326]

ImaiTInoueRKawadaYMoritaYInatomiONishidaAet alCharacterization of fungal dysbiosis in Japanese patients with inflammatory bowel disease