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In mice lacking glucose transporter 1 (GLUT1) in astrocytes, insulin-induced release of ATP is augmented and these mice are metabolically healthier [225] and show enhanced glucose metabolism and higher resilience to stroke [226]

A number of cellular stress factors, including hypoxia, nutrient deprivation, and ROS, are important stimuli of angiogenic signaling [220]

Acknowledgements This work was supported by grants from the Singapore Ministry of Education Academic Research Fund (T1-2011 Sep-05 and T1-2014 Apr -05) awarded to YC Long

However, the same study found that selenium supplementation did not have a significant impact on the levels of TSH receptor autoantibodies or on the proliferation of T-cells (94)