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In a mouse model of stroke, intracerebroventricular sodium selenate treatment elevates GPX4 levels by activating transcription factors activating enhancer binding protein 2 and specificity protein 1, while also providing protection against excitotoxicity and endoplasmic reticulum stress-induced cell death independent of GPX4 (102)

3 Diabetic kidney disease (DKD) affects 3040% of people with diabetes globally, with higher rates in type 1 diabetes (~40% after 20 years) and significant regional variationsaccounting for 4050% of end-stage renal disease (ESRD) cases in developed countries

The monoclonal antibody 18B7 completed Phase I trials in cryptococcal meningitis patients (Larsen et al., 2005)

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