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2 B12 deficiency can be due to inadequate dietary intake, in particular in people following a strict vegan diet (B12 is only found in animal foods)

A critical member of this network is cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB), which is phosphorylated in response to adrenergic signaling (e.g., exercise, cold) and binds directly to the cAMP response element (CRE) in the PGC-1 promoter to initiate transcription

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