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These findings suggest a potential link between OS, pathological calcium signaling, mitochondrial dysfunction, and the amplification of inflammation in canine pancreatitis through ROS

Finally, considering that mitochondria emerged as the most sensitive organelle to Cu toxicity in Wilson disease 13,31 , we investigated the impact of PrP suppression on mitochondrial function

Protein expression of several SLC transporters was reported to be altered at the BBB of AD patients (52, 202), which can affect the BBB permeation of drugs, substrates of these transporters

GSH acts as a potent antioxidant, protecting cells from oxidative damage, while GSSG is formed when GSH is oxidized