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Hanauer et al

Rap1-mediated activation of extracellular signal-regulated kinases by cyclic AMP is dependent on the mode of Rap1 activation

It aids the liver and kidneys in removing environmental pollutants

However, due to poor intrinsic sensitivity of NMR and the need to accumulate each NMR spectrum for ~4 min, the glyoxalase reactions appeared to be too fast to study in intact cells and tissues (going to completion in 10,000 times in liquid-state NMR