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Yes, lions mane is often classified as an adaptogen

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5HT1A receptors are known to negatively regulate serotonin neurons and are expressed as presynaptic autoreceptors in the raphe nucleus and postsynaptic receptors on cortical, hippocampus, hypothalamic and spinal regions, implicated in emotion, mood, motor activity, and stress responses (Drevets et al

It has been demonstrated in mice with adipocytes deficient in mitochondrial transcription factor A that isolated mitochondrial dysfunction in adipose tissue can cause lipodystrophy and lead to MS and chronic inflammation (Vernochet et al., 2014)