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Abstract Melatonin is multifaceted neurohormone secreted by pineal gland during darkness which is regulated by a small region present in hypothalamus i.e

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Second, cell type and microenvironmental specificity are insufficiently addressed: most research centers on renal tubular epithelial cells, while the role of ferroptosis in other renal resident cells (e.g., podocytes and mesangial cells) or infiltrating immune cells (e.g., macrophages and neutrophils) during I/R injury is largely unexplored