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Furthermore, consistent with the immune-linked neurotoxicity/neuroprotection theory, this meta-analysis revealed elevated levels of quinolinic acid, which is strongly neurotoxic, and decreased levels of kynurenic acid, which is neuroprotective, in MDD patients with melancholic and psychotic features [135]

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Lpez-Machado A, Daz N, Cano A, Espina M, Bada J, Baldom L, et al

IGFBP-3 is greatly reduced in subjects with severe Primary IGFD, resulting in increased clearance of IGF-1 in these subjects relative to healthy subjects