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Studies have demonstrated that the polarization of macrophages is controlled by multiple metabolic pathways, such as glycolysis, the pentose phosphate pathway, fatty acid oxidation, sphingolipid metabolism, the tricarboxylic acid cycle, and arginine metabolism

NAFLD iPSC-Heps exhibited higher endogenous FAO compared to controls (difference of 2772 pmol O 2 /min/10 6 cells, p =0.006)

doi: 10.1021/np9005212

Although these models are instrumental for mechanistic studies, they fail to fully recapitulate the multifactorial and long-term nature of human ovarian aging, which is shaped by decades of environmental exposures, metabolic comorbidities, genetic heterogeneity, and chronic inflamm-aging settings (Wang et al., 2025